Performance / Research index
MOTS-c
MOTS-c is investigated as a mitochondria-related peptide signal. Measuring it during exercise does not demonstrate the effects of administering it.
Names used in the literature: MOTS-c · MOTS-C
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MOTS-c 10 mg
- Presentation
- 10 mg
- Catalog reference
- PMX-MOTSC-10
MOTS-c 40 mg
- Presentation
- 40 mg
- Catalog reference
- MOTS-40
Availability and documentation await confirmation. Listed quantities identify catalog presentations, not instructions for use.
The initial metabolic research
The 2015 paper described MOTS-c as a 16-amino-acid peptide encoded within mitochondrial DNA. In mice it observed prevention of age-related or high-fat-diet-induced insulin resistance. Its cellular and mouse experiments do not establish metabolic benefits in people.
Sources: [1]
Two evidence types in the exercise paper
The 2021 publication investigated physical performance in mice and measured endogenous MOTS-c in exercising humans. The human work observed expression in muscle and circulation. A response involving the body’s own peptide does not demonstrate the effectiveness or safety of an external presentation.
Sources: [2]
Questions about this reference
Did the exercise study give MOTS-c to the human participants?
The cited human component measured endogenous MOTS-c in response to exercise, distinct from administration experiments in mice.
Does the metabolic research establish a weight-loss product?
No. The cited cellular and animal models do not establish that clinical outcome.
Sources and original reading
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
- MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
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