Longevity / Research index
Epithalon
Epithalon, also spelled Epitalon, features in cellular telomere research. The lifetime of a culture is not a measurement of human longevity.
Names used in the literature: Epithalon · Epitalon · AEDG
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Epithalon 10 mg
- Presentation
- 10 mg
- Catalog reference
- PMX-EPIT-10
Availability and documentation await confirmation. Listed quantities identify catalog presentations, not instructions for use.
Which compound and which cells
The sequence AEDG identifies alanine, glutamate, aspartate and glycine. A 2003 study reported telomerase activity and telomere elongation in cultured human fetal fibroblasts. Human origin of the cells does not make the experiment a clinical trial.
Cell divisions versus an organism’s lifespan
In 2004, the same group examined the division capacity of fetal lung fibroblasts in culture and described additional divisions. The endpoint was cellular proliferation. It did not measure years of life, physical function or disease prevention in human participants.
Sources: [2]
A later publication and its correction
A 2025 study described telomere lengthening involving telomerase in normal cells and the ALT pathway in tumor cell lines. The publisher later corrected figures 1, 2 and 3. Both records are linked. These remain cellular findings, not evidence of an anti-aging benefit in people.
Questions about this reference
Do Epitalon and Epithalon refer to the same peptide in these sources?
Yes. The linked papers use both spellings; AEDG helps specify the identity.
Sources and original reading
- Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
- Peptide promotes overcoming of the division limit in human somatic cell
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
- Correction: Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
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