Metabolism / Research index
5-Amino-1MQ
5-Amino-1MQ is a small molecule investigated as an inhibitor of nicotinamide N-methyltransferase, or NNMT. Its appearance alongside peptides does not make it a peptide. The studies discussed here concern metabolism and body composition in mice.
Names used in the literature: 5-Amino-1MQ · 5-amino-1-methylquinolinium · 5A1MQ
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5-Amino-1MQ 10 mg
- Presentation
- 10 mg
- Catalog reference
- PMX-5A1MQ-10
Availability and documentation await confirmation. Listed quantities identify catalog presentations, not instructions for use.
A molecule targeting NNMT
The 2017 publication describes a series of NNMT inhibitors and experiments involving 5-amino-1MQ in mice with diet-induced obesity. Researchers examined weight, adipose tissue and cholesterol. Identifying an enzyme target explains the experimental question; it does not establish the compound as an intervention with demonstrated clinical effectiveness.
Sources: [1]
Why the model’s diet matters
The 2021 study combined NNMT inhibition with a dietary change in mice. This helps investigate the interaction between the two interventions, but that context must remain attached to the findings. Assigning every body-composition change to the compound while omitting the diet and comparison group would misrepresent the experiment.
Sources: [2]
What later research added
A 2024 study examined metabolic measurements, liver histology and tissue distribution in mice. It broadens the preclinical characterization without establishing effectiveness or safety in people. Exposure measurements and liver findings address different questions from sustained clinical improvement. These distinctions matter when comparing an abstract with a product description.
Sources: [3]
The microbiome also has context
Another study examined the mouse microbiome during an intervention combining diet and NNMT inhibition. It describes a particular experimental association, rather than demonstrating an intestinal health benefit in people.
Sources: [4]
Questions about this reference
Are 5-Amino-1MQ and NAD+ the same substance?
No. 5-Amino-1MQ is investigated for NNMT inhibition; it is not NAD+ or an equivalent presentation of that coenzyme. A shared metabolic research context does not make their identities interchangeable.
Do the mouse findings predict weight loss in people?
They do not establish that conclusion. Study design, diet, exposure and species limit their interpretation. They also do not certify the contents or performance of an individual catalog presentation.
Sources and original reading
- Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
- Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice
- Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction
- Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice
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