Regeneration / Research index
GHK-Cu
GHK-Cu is studied in extracellular-matrix research. The cited models examine mechanisms rather than establish cosmetic outcomes.
Names used in the literature: GHK-Cu · Copper GHK · Glycyl-L-histidyl-L-lysine copper
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GHK-Cu 50 mg
- Presentation
- 50 mg
- Catalog reference
- PMX-GHK-100
GHK-Cu 100 mg
- Presentation
- 100 mg
- Catalog reference
- PMX-GHK-100MG
Availability and documentation await confirmation. Listed quantities identify catalog presentations, not instructions for use.
Identity of the complex
GHK denotes glycine, histidine and lysine; GHK-Cu identifies its copper complex. Retain the suffix when comparing documents.
Sources: [1]
Collagen in cell culture
In 1988, fibroblasts exposed to GHK-Cu showed increased collagen synthesis, independent of cell number. The experiment did not evaluate wrinkle reduction in participants.
Sources: [1]
What the animal model adds
A 1993 study used experimental wound chambers in rats. The authors observed greater accumulation of connective-tissue components, including collagen and glycosaminoglycans. That controlled setting differs from intact skin and a finished cosmetic formulation. The finding cannot be assigned automatically to every formulation or batch bearing the same ingredient name.
Sources: [2]
Questions about this reference
Does increased collagen in culture establish a cosmetic benefit?
No. The experiment did not evaluate cosmetic outcomes in people.
What did the wound study add to the culture experiment?
It examined connective-tissue accumulation in rat wound chambers, a different model from isolated fibroblasts.
Sources and original reading
- Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+
- In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds
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