Peptides MEX / Glossary
Purity ≥99%: what a percentage actually measures
A percentage needs a calculation basis and an identified sample to become useful information.
Updated · Sources and editorial standards
The basis of the percentage
A chromatographic estimate may be calculated from peak areas. Signal proportion is not automatically a fraction of total mass: detector response and calculation delimit the result. Purity ≥99% without a method leaves the measured property undefined.
Which questions remain open
Look for batch, method, detector and components included in the calculation. Identity, content and potency need their own evaluation. If a certificate reports only chromatographic purity, do not extend it to sterility, endotoxin absence or clinical suitability.
Questions about this reference
Sources and original reading
- Agilent OpenLab CDS for Automated High Throughput Purity Assessment Using Mass Spectrometry — Part I
- FDA: Part IV — Analytical
- NIST archived RM 8327 report: UV area purity and peptide mass purity
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