Peptides MEX / Glossary
Peptide coupling: bond formation during synthesis
A synthesis step names a transformation; it does not establish the quality of the material obtained.
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The reaction that joins two units
Peptide coupling forms an amide bond between an amino group and a carboxyl group prepared to react. Protecting groups help direct the reaction to the intended site. Coupling means a chemical transformation, rather than simply mixing two amino acids.
Sources: [1]
Reading a synthesis scheme
In a scheme alternating deprotection and coupling, the first step exposes a reactive group and the second extends the chain. Subsequent purification addresses which components remain in the mixture. The coupling reagent name does not establish product purity.
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Questions about this reference
Are coupling and purification equivalent?
No. Coupling constructs a bond; purification separates mixture components.
Sources and original reading
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