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Peptides MEX

Peptides MEX / Glossary

Kisspeptin: peptide family, fragments and receptor

A family name does not necessarily identify the fragment used in a study.

Updated · Sources and editorial standards

Peptides and receptor have different names

Kisspeptins derive from the precursor encoded by KISS1. They interact with the kisspeptin receptor, associated with the name KISS1R and the historical designation GPR54. The ligand gene and receptor gene should not be confused.

Sources: [1][2]

Numbers identify fragments

Kisspeptin-10 and kisspeptin-54 designate peptides of different lengths. Record the fragment, species and available sequence or identifier when reviewing a paper. A finding mentioning only kisspeptin may lack enough detail to compare materials.

Sources: [1][2]

Questions about this reference

Is KISS1R a form of kisspeptin?

No. Depending on context, it identifies the receptor or its gene, rather than a ligand fragment.

[1][2]

Sources and original reading

  1. NIH / NCBI: KISS1 gene
  2. IUPHAR: Kisspeptin Receptor Nomenclature, Distribution, and Function

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